邮箱：yaowang@bucm.edu.cn
个人简介
王遥，教授，博士生导师。2020年以“高层次人才”入职2278游戏中心官网。2023年入选中华中医药学会“青年人才托举工程”（A类）和北京市“科技新星”计划。围绕固有免疫相关疾病的发病机制与中医药干预策略开展研究，以通讯或第一作者发表论文十余篇，包括Nature Cell Biology, Nature Communications, Acta Pharmaceutica Sinica B等。成果被Nature, Nature Review等重要刊物述评或引用500余次，授权专利4项。先后主持国家自然科学基金、北京市“科技新星”、北京市面上、广东省面上等7项课题。担任中华中医药学会免疫学分会、感染病分会、中药分析分会委员，中国药品监管研究会中药监管专委会委员及《中草药》杂志青年编委。
研究方向
1.针对清热中药生物碱类、黄酮类药效成分开展系统研究，阐明相似化学结构免疫调控的共性药理机制。
2. 利用基因编辑技术构建基因敲除动物及细胞模型，围绕固有免疫调控及相关疾病，揭示免疫调控新机制、阐明免疫稳态失衡与疾病发生的原理。
主要成果
1. Tong Luo#, Xin Jia#, Wandi Feng#, Jinyong Wang, Fang Xie, Lingdong Kong, Xuejiao Wang, Rui Lian, Xia Liu, Yingjie Chu, Yao Wang*, Anlong Xu*. Bergapten suppresses NLRP3 inflammasome activation and pyroptosis via promoting mitophagy. Acta Pharmacologica Sinica. 44(9):1867-1878 (2023) 中科院一区
2. Haojia Wang#, Xin Jia#, Meiqi Zhang#, Cuiqin Cheng, Xue Liang, Xuejiao Wang, Fang Xie, Jinyong Wang, Yanli Yu, Yuting He, Qiutong Dong, Yao Wang*, Anlong Xu#. Isoliquiritigenin inhibits virus replication and virus-mediated inflammation via NRF2 signaling. Phytomedicine. 114:154786 (2023) 中科院一区
3. Meiqi Zhang#, Xin Jia#, Cuiqin Cheng, Yuxi Wang, Yiying Li, Lingdong Kong, Qiqi Li, Fang Xie, Yanli Yu, Yuting He, Qiutong Dong, Zhanhong Jia, Yao Wang*, Anlong Xu#. Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection. Acta Pharmacologica Sinica. 44(11):2253-2264 (2023) 中科院一区
4. Wandi Feng#, Yao Wang#, Tong Luo, Xin Jia, Cuiqin Cheng, Haojia Wang, Meiqi Zhang, Qiqi Li, Xuejiao Wang, Yiying Li, Jinyong Wang, Guangrui Huang, Ting Wang, Anlong Xu*. Scoparone suppresses mitophagy-mediated NLRP3 inflammasome activation in inflammatory diseases. Acta Pharmacologica Sinica. 44(6):1238-1251 (2023) 中科院一区
5. Xue Liang#, Kunpeng Liu#, Xin Jia#, Cuiqin Cheng, Meiqi Zhang, Lingdong Kong, Qiqi Li, Zhe Liu, Min Lie, Junliang Li, Yao Wang*, Anlong Xu*. Suppressing FXR promotes antiviral effects of bile acids via enhancing the interferon transcription. Acta Pharmaceutica Sinica B. (已接收) 中科院一区TOP期刊
6. Jinyong Wang#, Fang Xie#, Xin Jia#, Xuejiao Wang，Lingdong Kong，Yiying Li， Xue Liang，Meiqi Zhang，Yuting He，Wandi Feng，Tong Luo，Yao Wang*，Anlong Xu*.Fangchinoline Induces Antiviral Response by Suppressing STING Degradation. Journal of Pharmaceutical Analysis. (已接收) 中科院一区
7. Xin Jia, Meiqi Zhang, Haojia Wang, Cuiqin Cheng, Qiqi Li, Yiying Li, Lingdong Kong, Xihong Lan, Yuxi Wang, Xue Liang, Shaochun Yuan*, Yao Wang*, Anlong Xu*. ZNFX1 antisense RNA1 promotes antiviral innate immune responses via modulating ZNFX1 function. Journal of Medical Virology. 95(3):e28637 (2023). IF: 20.69 TOP期刊
8. Yao Wang#, Shaochun Yuan#, Xin Jia#, Yong Ge, Tao Ling, Meng Nie, Xihong Lan, Shangwu Chen, Anlong Xu*. Mitochondria-localized ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS. Nature Cell Biology. 21(11): 1346~1356. (2019) 中科院一区TOP期刊
9. Xin Jia#, Shaochun Yuan#, Yao Wang#, Yonggui Fu, Yong Ge, Yutong Ge, Xihong Lan, Yuchao Feng, Feifei Qiu, Peiyi Li, Shangwu Chen, Anlong Xu*. The role of alternative polyadenylation in the antiviral innate immune response. Nature Communications. 8:14605. (2017) 中科院一区TOP期刊
10. Yong Ge*, Tao Ling*, Yao Wang, Xin Jia, Xiongmei Xie, Rong Chen, Shangwu Chen， Shaochun Yuan#，Anlong Xu#. Degradation of WTAP blocks antiviral responses by reducing the m6A levels Of IRF3 and IFNAR1 mRNA. EMBO Reports. e52101.(2021)中科院一区
相关专利列表：
1. 徐安龙，王遥，贾鑫，张美琦，李琪琪，王雪娇，成翠芹，孔令东，黄光瑞 广谱抗病毒中药单体小檗胺及其应用.中国专利，2022.8.15专利号：ZL202210976102.1
2. 徐安龙，王遥，贾鑫，成翠芹，王浩嘉，张美琦，黄光瑞 广谱抗病毒药物、及其药物组合物和应用. 中国专利，2021.12.7专利号：ZL202111484730.X
3. 徐安龙，贾鑫，王遥，成翠芹，王靳勇，谢芳，张美琦，李艺颖，王浩嘉 广谱抗病毒中药单体汉防己乙素及其应用. 中国专利，2022.8.15专利号：ZL202210976106.X
4. 徐安龙，王遥，贾鑫，初英杰，李琪琪，王雪娇，禹艳丽，成翠芹，李俊良.抗病毒中药提取物北豆根总生物碱及其应用. 中国专利，2023-11-15申请号：202311518042.X
联系方式：
yaowang@bucm.edu.cn