邮箱：201810122@bucm.edu.cn
个人简介
王婧筱，2278游戏中心官网副研究员，硕士生导师。2278游戏中心官网中医学七年制免试推博生，中西医结合肿瘤学博士，加州大学旧金山分校药学院联合培养博士，斯坦福大学医学院博士后。获北京市科技新星、国自然青年等课题支持，所研发创新动物模型及相关研究获美国肝胆癌病理及转化前沿大会“早期研究者”奖；研究内容摘要刊登于美国ASCO年会，收录予Journal of Clinical Oncology。获得已授权实用新型专利1项，发明专利1项。
研究方向
应用现代科学技术手段研究中医临床效方验方的药效机制，揭示中医科学问题；肿瘤类器官药物筛选体系构建；肝癌分子机制研究。
主要成果
1. Wang J*, Wang H*, Peters M, Ribback S, Utpatel K, Cigliano A, Dombrowski F, Xu M, Song X, Che L, Evert M, Cossu A, Gordan J, Chen X, Calvisi DF. Loss of Fbxw7 synergizes with activated AKT signaling to promote c-Myc dependent cholangiocarcinogenesis. Journal of Hepatology. 2019. PMID: 31195063. IF 30.1
2. Lu X, Peng B, Chen G, Mario G. P, Silvia R, Cindy A, Xu H, Pal R, Rodrigues P, Banales J, Evert M, Calvisi D, Chen X, Fan B#, Wang J#. YAP Accelerates Notch-Driven Cholangiocarcinogenesis via mTORC1 in Mice. The American Journal of Pathology. 2021. https://doi.org/10.1016/j.ajpath.2021.05.017. IF 5.8
3. Xu M*, Wang J*, Xu Z, Li R, Wang P, Shang R, Wang H, Song X, Che L, Zhang S, Calvisi DF, Liu X, Chen X. SNAI1 Promotes the Cholangiocellular Phenotype, but not Epithelial-Mesenchymal Transition, in a Murine Hepatocellular Carcinoma Model. Cancer Research. 2019. PMID: 31383647. IF 13.3
4. Wang J*, Dong M*, Xu Z, Song X, Zhang S, Qiao Y, Che L, Gordan J, Hu K, Liu Y, Calvisi DF, Chen X. Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice. Oncogene. 2018 Mar 16. PMID: 29545603. IF 8.7
5. Wang H*, Wang J*, Zhang S, Jia J, Liu X, Zhang J, Wang P, Song X, Che L, Liu K, Ribback S, Cigliano A, Evert M, Wu H, Calvisi DF, Zeng Y, Chen X. Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33232824. IF 8.8
6. Nie J*, Jiang X*, Wang G, Xu Y, Pan R, Yu W, Li Y#, Wang J#. Yu-Ping-Feng-San Alleviates Inflammation in Atopic Dermatitis Mice by TLR4/MyD88/NF-kB Pathway. Journal of Ethnopharmacology. 2024. (Accepted). IF 5.6
7. Yu S*, Wang J*, Zheng H, Wang R, Johnson N, Li T, Li P, Lin J, Li Y, Yan J, Zhang Y, Zhu Z, Ding X. Pathogenesis from Inflammation to Cancer in NASH-Derived HCC. J Hepatocell Carcinoma. 2022 Aug 26;9:855-867. doi: 10.2147/JHC.S377768. PMID: 36051860. IF 4.6